Concomitant usage of benzodiazepines and opioids could end in profound sedation, respiratory depression, coma, and Demise. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment choices are inadequate.
are pregnant or intend to become pregnant. VALIUM may well damage your unborn newborn. You and your healthcare service provider really should decide if you ought to take VALIUM while you're pregnant.
If you take too much VALIUM, call your Health care company or visit the closest clinic emergency area straight away.
In equally untimely and entire term infants the Lively metabolite desmethyldiazepam demonstrates evidence of ongoing accumulation in comparison to children. Longer half-life in infants can be because of incomplete maturation of metabolic pathways.
Diazepam is just not proposed within the treatment of psychotic patients and shouldn't be used as an alternative to appropriate treatment.
Risks from Concomitant Use with Opioids Advise both equally patients and caregivers in regards to the risks of doubtless lethal respiratory depression and sedation when diazepam tablets are used with opioids instead of to utilize these types of drugs concomitantly Unless of course supervised by a wellbeing care company.
It is actually used to treat alcohol, opiate, and benzodiazepine withdrawal because of its comparatively long “half-life”. A drug’s “half-life” is the quantity of time it takes for the active substance of a drug to scale back by half in Your system. [one]
In patients by now receiving an opioid analgesic, prescribe a lower initial dose of diazepam tablets than indicated during the absence of the opioid and titrate based on clinical response. If an opioid is initiated in the patient by now taking diazepam tablets, prescribe diazepam dosing a lower initial dose in the opioid and titrate based mostly upon medical response. Recommend each patients and caregivers with regards to the threats of respiratory depression and sedation when diazepam tablets are used with opioids. Advise patients to not generate or operate significant machinery till the effects of concomitant use with the opioid have already been determined (see Safeguards: Drug Interactions).
In case you all of a sudden prevent taking diazepam immediately after many months of treatment, you may working experience withdrawal symptoms which could make your pregnancy more challenging.
Comprehensive accumulation of diazepam and its important metabolite, desmethyldiazepam, is observed adhering to Persistent administration of diazepam in wholesome elderly male subjects. Metabolites of this drug are identified being substantially excreted by the kidney, and the potential risk of toxic reactions may very well be better in patients with impaired renal function.
An elevated threat of congenital malformations and other developmental abnormalities related with the usage of benzodiazepine drugs in the course of pregnancy has become advised. There may also be nonteratogenic threats involved with the usage of benzodiazepines through pregnancy. There are actually reports of neonatal flaccidity, respiratory and feeding challenges, and hypothermia in children born to mothers who are obtaining benzodiazepines late in pregnancy.
You will find there's dilemma with information submitted for this ask for. Overview/update the information highlighted under and resubmit the form.
The subsequent drugs may prolong the effects of diazepam by inhibiting liver enzymes that remove diazepam:
Valium is contraindicated in patients with a regarded hypersensitivity to diazepam and, due to deficiency of ample clinical knowledge, in pediatric patients beneath six months of age. Valium can also be contraindicated in patients with myasthenia gravis, significant respiratory insufficiency, intense hepatic insufficiency, and sleep apnea syndrome.